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Abstract
Cancer wounds are complex wounds with various challenges, and one of essential interventions used is chemotherapy. However, the clin-ical effects of chemotherapy on the status of cancer wounds have not been extensively reviewed, raising the question of whether it has bene-ficial or detrimental effects. The study wanted to identify whether chemotherapy can induce autolytic debridement. A prospective case study involved a patient who underwent four treatment sessions in a regional hospital in eastern Indonesia. Wound assessment was per-formed using the Bates-Jensen Wound Assessment Tool (BWAT). In the first wound treatment, the BWAT score was 38; by the fourth treat-ment, the score increased to 45, suggesting a worsening of the wound status. However, this anomaly is positive for the wound status, as au-tolysis occurred in the slough and necrotic tissue resulting from the chemotherapy.This case study illustrates the positive effect of chemo-therapy on necrotic and slough tissue by inducing autolytic debride-ment.
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References
2 F. Firmino, D. L. Villela-Castro, J. dos San-tos, and V. L. Conceicao de Gouveia Santos : Topical Management of Bleeding From Malignant Wounds Caused by Breast Can-cer : A Systematic Review, Elsevier Inc, 2021;6, doi: 10.1016/j.jpainsymman.2020.10.020.
3 A. Combalia and C. Carrera : Squamous Cell Carcinoma : An Update on Diagnosis and Treatment, Dermatol Pract Concept, p. e2020066, Jun. 2020;6, doi: 10.5826/dpc.1003a66.
4 R. Farghadani and R. Naidu : Curcumin as an Enhancer of Therapeutic Efficiency of Chemotherapy Drugs in Breast Cancer, MDPI, 2022;2, doi : 10.3390/ijms23042144.
5 Caka Amjad MT : Cancer Chemotherapy, 2023, doi: https://www.ncbi.nlm.nih.gov/books/NBK564367/
6 L. Bracci, G. Schiavoni, A. Sistigu, and F. Belardelli : Immune-based mechanisms of cytotoxic chemotherapy: Implications for the design of novel and rationale-based combined treatments against cancer, 2014;1. doi: 10.1038/cdd.2013.67.
7 J. S. D. Mieog, J. A. Van Der Hage, and C. J. H. Van De Velde : Preoperative chemo-therapy for women with operable breast cancer, John Wiley and Sons Ltd. 2007 doi: 10.1002/14651858.CD005002.pub2.
8 M. M. Rampurwala, G. B. Rocque, and M. E. Burkard : Update on adjuvant chemother-apy for early breast cancer, Breast Cancer (Auckl), pp. 125–133, 2014;10, doi: 10.4137/BCBCR.S9454.
9 M. Lyu, Y. Shen, N. Beharee, J. Lu, F. Deng, and J. Wang : The combined use of chemo-therapy and radiotherapy with PD-1 inhib-itor, pembrolizumab, in advanced cervical cancer : A case report, Onco Targets Ther, pp. 4465–4471, 2020, doi: 10.2147/OTT.S245190.
10 P. Słonimska, P. Sachadyn, J. Zielinski, M. Skrzypski, and M. Pikuła, Chemotherapy-Mediated Complications of Wound Healing : An Understudied Side Effect, Mary Ann Liebert Inc. 2024;4 doi: 10.1089/wound.2023.0097.
11 J. , S. A. , & E. S. Dissemond : Autolytic deb-ridement of chronic wounds : Internation-al Wound Journal, 14(6), 1235-1241, 2017, doi: doi: 10.1111/iwj.12792.
12 B. M. Bates-Jensen, H. E. McCreath, D. Harputlu, and A. Patlan : Reliability of the Bates-Jensen wound assessment tool for pressure injury assessment : The pressure ulcer detection study, Wound Repair and Regeneration, 27(4) pp. 386–395, 2019;7, doi: 10.1111/wrr.12714.
13 S. Gupta, A. Srivastava, R. Malhotra, M. Chadha, and A. N. Aggarwal, : Wound As-sessment Using Bates Jensen Wound As-sessment Tool in Acute Musculoskeletal In-jury Following Low-Cost Wall-Mounted Negative-Pressure Wound Therapy Appli-cation, Indian J Orthop, 57(6) pp. 948–956, 2023;6 , doi: 10.1007/s43465-023-00861-2.
14 R. D. , & F. J. Wolcott : Technology update: role of wound cleansing in the manage-ment of wounds, 2014.
15 D. Dayya, O. J. O’Neill, T. B. Huedo-Medina, N. Habib, J. Moore, and K. Iyer, : Debride-ment of Diabetic Foot Ulcers, Mary Ann Liebert Inc. 2022;12 doi: 10.1089/wound.2021.0016.
16 V. Brumberg, T. Astrelina, T. Malivanova, and A. Samoilov, Modern wound dressings: Hydrogel dressings, 2021;09, MDPI. doi: 10.3390/biomedicines9091235.
17 A. Furka et al., : Treatment Algorithm for Cancerous Wounds: A Systematic Review,” Cancers (Basel), p. 1203, 2022, doi : 10.3390/cancers.
18 S. D. , & J. V Bateman, “Autolytic debride-ment of chronic wounds: An overview,” Advances in Wound Care, 5(10), 455-461, 2016, doi: doi: 10.1089/wound.2016.0685.